No. 46's are a good choice for a 350p- PMD had a 350 HO in a 68 and 69 Firebird, and it had no. 48 heads (similar chamber size but bigger valves). The small chamber heads will give you a healthy bump in power from the 7.6:1 SCR with the 6x-4's- expect around 9-9.2:1 SCR. I would have the heads serviced first (valve job, guides reamed or liners installed, surfaced, exhaust seats installed). These heads should make at least 300 hp with a good cam like a summit 2800, Crane 283941, or Crower 60916 and headers with a dual exhaust.